8FFV
Cryo-EM structure of the GR-Hsp90-FKBP52 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-alpha | polymer | 731 | 84650.5 | 2 | UniProt (P07900) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (human) | Heat shock 86 kDa,HSP 86,HSP86,Lipopolysaccharide-associated protein 2,LAP-2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C (C) | Glucocorticoid receptor | polymer | 360 | 41199.0 | 1 | UniProt (P04150) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 3 | D (D) | Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed | polymer | 459 | 51876.5 | 1 | UniProt (Q02790) Pfam (PF00254) Pfam (PF00515) | Homo sapiens (human) | |
| 4 | E, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | I (C) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) |
Sequence modifications
C: 418 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 262376.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1455.4 | |
| All* | Total formula weight | 263832.0 |
