8FFO
Cryo-EM structure of wildtype rabbit TRPV5 with PI(4,5)P2 in nanodiscs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 5 | polymer | 739 | 83784.6 | 4 | UniProt (Q9XSM3) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) | Oryctolagus cuniculus (rabbit) | TrpV5,Epithelial calcium channel 1,ECaC1,Osm-9-like TRP channel 3,OTRPC3 |
| 2 | AA, E, EA, I, M... (D, A, B, C) | ERGOSTEROL | non-polymer | 396.6 | 8 | Chemie (ERG) | |||
| 3 | BA, CA, DA, F, G... (D, A, B, C) | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 758.1 | 16 | Chemie (CPL) | |||
| 4 | FA, J, R, Y (D, A, B, C) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 4 | Chemie (PIO) |
Sequence modifications
A, B, C, D: 1 - 730 (UniProt: Q9XSM3)
| PDB | External Database | Details |
|---|---|---|
| Thr 731 | - | expression tag |
| Glu 732 | - | expression tag |
| Thr 733 | - | expression tag |
| Ser 734 | - | expression tag |
| Gln 735 | - | expression tag |
| Val 736 | - | expression tag |
| Ala 737 | - | expression tag |
| Pro 738 | - | expression tag |
| Ala 739 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 335138.3 | |
| Non-Polymers* | Number of molecules | 28 |
| Total formula weight | 18288.4 | |
| All* | Total formula weight | 353426.8 |
