8FE9
Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Activated CDC42 kinase 1 | polymer | 286 | 32437.3 | 1 | UniProt (Q07912) Pfam (PF07714) In PDB | Homo sapiens (human) | ACK-1,Tyrosine kinase non-receptor protein 2 |
| 2 | A | N-[(1S)-1-benzyl-2-[(6-chloro-2-oxo-1H-quinolin-4-yl)methylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carbo | non-polymer | 543.0 | 1 | Chemie (R9B) | |||
| 3 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 110 - 391 (UniProt: Q07912)
| PDB | External Database | Details |
|---|---|---|
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gln 161 | Lys 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32437.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 543.0 | |
| All* | Total formula weight | 32980.3 |
