8FE9
Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activated CDC42 kinase 1 | polymer | 287 | 32494.4 | 1 | UniProt (Q07912) Pfam (PF07714) | Homo sapiens (human) | ACK-1,Tyrosine kinase non-receptor protein 2 |
| 2 | B (A) | 5-chloro-N~2~-[4-(4-methylpiperazin-1-yl)phenyl]-N~4~-{[(2R)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine | non-polymer | 402.9 | 1 | Chemie (WTP) |
Sequence modifications
A: 110 - 391 (UniProt: Q07912)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ala 106 | - | expression tag |
| Met 107 | - | expression tag |
| Gly 108 | - | expression tag |
| Ser 109 | - | expression tag |
| Gln 161 | Lys 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32494.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 402.9 | |
| All* | Total formula weight | 32897.3 |
