8FDU
Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase | polymer | 3126 | 357459.1 | 1 | UniProt (Q14204) UniProt (Q5SJX7) Pfam (PF08393) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) Pfam (PF12780) Pfam (PF12777) Pfam (PF02403) Pfam (PF12781) In PDB | Homo sapiens (human) | Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic,Seryl-tRNA synthetase,SerRS,Seryl-tRNA(Ser/Sec) synthetase |
2 | B, C | Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag | polymer | 598 | 66423.5 | 2 | UniProt (P43034) Pfam (PF08513) Pfam (PF00400) In PDB | Homo sapiens (human) | Lissencephaly-1 protein,LIS-1,PAF acetylhydrolase 45 kDa subunit,PAF-AH 45 kDa subunit,PAF-AH alpha,PAFAH alpha |
3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
A: 3 - 1822 (UniProt: Q14204)
A: 1823 - 1889 (UniProt: Q5SJX7)
A: 1890 - 3124 (UniProt: Q14204)
B, C: 3 - 411 (UniProt: P43034)
B, C: 412 - 598 (PDB: 8FDU)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
A: 1890 - 3124 (UniProt: Q14204)
PDB | External Database | Details |
---|---|---|
Glu 3125 | - | expression tag |
Phe 3126 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 490306.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 854.4 | |
All* | Total formula weight | 491160.6 |