8FCB
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Transient receptor potential cation channel subfamily V member 4 | polymer | 871 | 98393.9 | 4 | UniProt (Q9HBA0) Pfam (PF00023) Pfam (PF00520) In PDB | Homo sapiens (human) | TrpV4,Osm-9-like TRP channel 4,OTRPC4,Transient receptor potential protein 12,TRP12,Vanilloid receptor-like channel 2,Vanilloid receptor-like protein 2,VRL-2,Vanilloid receptor-related osmotically-activated channel,VR-OAC |
2 | E, F, G, H | Transforming protein RhoA | polymer | 193 | 21799.2 | 4 | UniProt (P61586) Pfam (PF00071) In PDB | Homo sapiens (human) | Rho cDNA clone 12,h12 |
3 | A, B, C, D | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide | non-polymer | 655.6 | 4 | Chemie (XQ3) | |||
4 | B, C, D | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) | |||
5 | E, F, G, H | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 4 | Chemie (GSP) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 480772.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 6726.3 | |
All* | Total formula weight | 487498.7 |