8FBQ
Crystal structure of Plasmodium vivax glycylpeptide N-tetradecanoyltransferase (N-myristoyltransferase, NMT) bound to myristoyl-CoA and inhibitor 12b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glycylpeptide N-tetradecanoyltransferase | polymer | 386 | 45100.6 | 1 | UniProt (A5K1A2) Pfam (PF01233) Pfam (PF02799) In PDB | Plasmodium vivax | |
| 2 | A | TETRADECANOYL-COA | non-polymer | 977.9 | 1 | Chemie (MYA) | |||
| 3 | A | 1-[(3M)-3-{3-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]pyridin-2-yl}phenyl]piperazine | non-polymer | 391.5 | 1 | Chemie (XOQ) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | A | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 6 | A | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 7 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 8 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 9 | A | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
| 10 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 11 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 12 | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A: 27 - 410 (UniProt: A5K1A2)
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | - | expression tag |
| Pro 26 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45100.6 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 3354.0 | |
| All* | Total formula weight | 48454.5 |
