8FB2
HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 8 ANDINDAZOLE ACID BOUND IN H12-POCKET
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nuclear receptor ROR-gamma | polymer | 262 | 30250.8 | 2 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | C, E (A, B) | (1R,15S)-16-(cyclopropylacetyl)-5-fluoro-20-methyl-9lambda~6~-thia-1,8,16-triazatricyclo[13.3.1.1~3,7~]icosa-3(20),4,6-triene-9,9-dione | non-polymer | 437.6 | 2 | Chemie (XO5) | |||
| 3 | D, F (A, B) | 4-[1-(2,6-dichlorobenzoyl)-4-fluoro-1H-indazol-3-yl]benzoic acid | non-polymer | 429.2 | 2 | Chemie (XNX) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B: 259 - 517 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Ser 256 | - | expression tag |
| Met 257 | - | expression tag |
| Pro 258 | - | expression tag |
| Ser 278 | Cys 278 | engineered mutation |
| Ser 345 | Cys 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60501.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1733.6 | |
| All* | Total formula weight | 62235.2 |
