8FAV
HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 5 ANDINDAZOLE ACID BOUND IN H12-POCKET
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nuclear receptor ROR-gamma | polymer | 262 | 30250.8 | 2 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | C, F (A, B) | 3-cyano-N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)benzamide | non-polymer | 462.6 | 2 | Chemie (LKY) | |||
| 3 | D, G (A, B) | 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-3-fluorobenzoic acid | non-polymer | 480.8 | 2 | Chemie (4Y5) | |||
| 4 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A, B: 259 - 517 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Ser 256 | - | expression tag |
| Met 257 | - | expression tag |
| Pro 258 | - | expression tag |
| Ser 278 | Cys 278 | engineered mutation |
| Ser 345 | Cys 345 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60501.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1982.7 | |
| All* | Total formula weight | 62484.3 |
