8FAD
Asymmetric structure of cleaved HIV-1 AD8 envelope glycoprotein trimer in styrene-maleic acid lipid nanoparticles
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, F (B, D, F) | Transmembrane protein gp41 | polymer | 138 | 15674.9 | 3 | UniProt (P19550) | Human immunodeficiency virus 1 | TM,Glycoprotein 41,gp41 |
| 2 | B, D, E (C, E, A) | Envelope glycoprotein gp120 | polymer | 469 | 52779.6 | 3 | UniProt (B0FDK7) | Human immunodeficiency virus 1 | |
| 3 | AA, AB, BA, BB, DA... (a, 0, b, 1, d...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 35 | In PDB GlyTouCan (G42666HT) | |||
| 4 | GA, J, JA, N, Q... (g, J, j, N, Q...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 8 | In PDB GlyTouCan (G15407YE) | |||
| 5 | M (M) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 6 | R (R) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 7 | CA (c) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 8 | HA (h) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
| 9 | RA (r) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
| 10 | AC, CB, DB, EB, GB... (F, B, C, D, E...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 22 | Chemie (NAG) | |||
| 11 | FB, OB, TB (C, E, A) | 1-[(2R)-4-(benzenecarbonyl)-2-methylpiperazin-1-yl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)ethane-1,2-dione | non-polymer | 406.4 | 3 | Chemie (83G) |
Sequence modifications
B, D, F: 520 - 657 (UniProt: P19550)
| PDB | External Database | Details |
|---|---|---|
| Ala 533 | Arg 524 | conflict |
| Ile 535 | Leu 526 | conflict |
| Leu 543 | Gln 534 | conflict |
| Arg 588 | Lys 579 | conflict |
| Thr 618 | Ser 609 | conflict |
| Met 621 | Gln 612 | conflict |
| Gly 640 | Asn 631 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 205363.5 | |
| Branched | Number of molecules | 48 |
| Total formula weight | 24262.6 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 6085.9 | |
| All* | Total formula weight | 235712.0 |
