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8F7V

Macrocyclic plasmin inhibitor

Replaces:  7T52
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Plasminogenpolymer25027319.42UniProt (P00747)
Pfam (PF00089)
Homo sapiens (human)
2C, G
(A, B)
(6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(benzenesulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamidenon-polymer795.02Chemie (EUA)
3D, E, F, H, I...
(A, B)
SULFATE IONnon-polymer96.19Chemie (SO4)
4N
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
5O, P
(A, B)
waterwater18.0377Chemie (HOH)
Sequence modifications
A, B: 542 - 791 (UniProt: P00747)
PDBExternal DatabaseDetails
Ala 741Ser 760engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight54638.8
Non-Polymers*Number of molecules12
Total formula weight2546.6
All*Total formula weight57185.4
*Water molecules are not included.

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PDB entries from 2025-12-17

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