8F7P
BRAF kinase in complex with LXH254 (naporafenib)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 283 | 32014.7 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | non-polymer | 502.5 | 2 | Chemie (K81) | |||
3 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 441 - 723 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
Gly 441 | Leu 441 | conflict |
Gly 443 | Arg 443 | conflict |
Ala 446 | Ser 446 | conflict |
Ala 447 | Ser 447 | conflict |
Ala 543 | Ile 543 | conflict |
Ser 544 | Ile 544 | conflict |
Lys 551 | Ile 551 | conflict |
Arg 562 | Gln 562 | conflict |
Asn 588 | Leu 588 | conflict |
Ser 630 | Lys 630 | conflict |
Glu 667 | Phe 667 | conflict |
Ser 673 | Tyr 673 | conflict |
Arg 688 | Ala 688 | conflict |
Ser 706 | Leu 706 | conflict |
Arg 709 | Gln 709 | variant |
Glu 713 | Ser 713 | conflict |
Glu 716 | Leu 716 | conflict |
Glu 720 | Ser 720 | conflict |
Ser 722 | Pro 722 | conflict |
Gly 723 | Lys 723 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64029.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1005.0 | |
All* | Total formula weight | 65034.3 |