8F7O
BRAF kinase in complex with TAK580 (tovorafenib)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 283 | 32014.7 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, D (A, B) | 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide | non-polymer | 506.3 | 2 | Chemie (QOP) |
Sequence modifications
A, B: 441 - 723 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 441 | Leu 441 | conflict |
| Gly 443 | Arg 443 | conflict |
| Ala 446 | Ser 446 | conflict |
| Ala 447 | Ser 447 | conflict |
| Ala 543 | Ile 543 | conflict |
| Ser 544 | Ile 544 | conflict |
| Lys 551 | Ile 551 | conflict |
| Arg 562 | Gln 562 | conflict |
| Asn 588 | Leu 588 | conflict |
| Ser 630 | Lys 630 | conflict |
| Glu 667 | Phe 667 | conflict |
| Ser 673 | Tyr 673 | conflict |
| Arg 688 | Ala 688 | conflict |
| Ser 706 | Leu 706 | conflict |
| Arg 709 | Gln 709 | variant |
| Glu 713 | Ser 713 | conflict |
| Glu 716 | Leu 716 | conflict |
| Glu 720 | Ser 720 | conflict |
| Ser 722 | Pro 722 | conflict |
| Gly 723 | Lys 723 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64029.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1012.6 | |
| All* | Total formula weight | 65041.9 |
