8F76

Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Olfactory receptor 51E2	polymer	330	36651.5	1	UniProt (Q9H255) Pfam (PF13853)	Homo sapiens (human)	HPRAJ,Olfactory receptor OR11-16,Prostate-specific G-protein coupled receptor
2	B (N)	Nanobody 35	polymer	145	15931.7	1		Lama glama
3	C (X)	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	polymer	261	30137.0	1	UniProt (P63092) Pfam (PF00503)	Homo sapiens (human)	Adenylate cyclase-stimulating G alpha protein
4	D (Y)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	370	40786.6	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (human)	Transducin beta chain 1
5	E (Z)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
6	F (A)	PROPANOIC ACID	non-polymer		74.1	1	Chemie (PPI)

Sequence modifications

A: 2 - 320 (UniProt: Q9H255)

PDB	External Database	Details
Asp -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Ile 0	-	expression tag
Asp 1	-	expression tag

X: 5 - 195 (UniProt: P63092)

PDB	External Database	Details
Gly -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Leu -4	-	expression tag
Glu -3	-	expression tag
Val -2	-	expression tag
Leu -1	-	expression tag
Phe 0	-	expression tag
Gln 1	-	expression tag
Gly 2	-	expression tag
Pro 3	-	expression tag
Ser 4	-	expression tag
Asp 49	Gly 49	conflict
Asn 50	Glu 50	conflict

X: 204 - 394 (UniProt: P63092)

PDB	External Database	Details
Gly 196	-	linker
Gly 197	-	linker
Ser 198	-	linker
Gly 199	-	linker
Gly 200	-	linker
Ser 201	-	linker
Gly 202	-	linker
Gly 203	-	linker
Asp 249	Ala 249	conflict
Asp 252	Ser 252	conflict
-	Asn 254	deletion
-	Met 255	deletion
-	Val 256	deletion
-	Ile 257	deletion
-	Arg 258	deletion
-	Glu 259	deletion
-	Asp 260	deletion
-	Asn 261	deletion
-	Gln 262	deletion
-	Thr 263	deletion
Ala 372	Ile 372	conflict
Ile 375	Val 375	conflict

Y: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -29	-	initiating methionine
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
Leu -22	-	expression tag
Glu -21	-	expression tag
Val -20	-	expression tag
Leu -19	-	expression tag
Phe -18	-	expression tag
Gln -17	-	expression tag
Gly -16	-	expression tag
Pro -15	-	expression tag
Glu -14	-	expression tag
Asp -13	-	expression tag
Gln -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Pro -9	-	expression tag
Arg -8	-	expression tag
Leu -7	-	expression tag
Ile -6	-	expression tag
Asp -5	-	expression tag
Gly -4	-	expression tag
Lys -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Ser 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	131368.0
Non-Polymers*	Number of molecules	1
	Total formula weight	74.1
All*	Total formula weight	131442.1

*Water molecules are not included.