8F1H
EGFR kinase in complex with TAS6417 (CLN-081)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 331 | 37636.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | N-[(5P,8S,10R)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide | non-polymer | 396.4 | 1 | Chemie (X9H) | |||
3 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
4 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ser 693 | - | expression tag |
Thr 694 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37636.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 588.6 | |
All* | Total formula weight | 38225.0 |