8EYB
Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with JAK2 activation loop phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 296 | 34311.1 | 2 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | C, D (D, E) | Tyrosine-protein kinase JAK2 activation loop phosphopeptide | polymer | 16 | 2005.1 | 2 | UniProt (O60674) | Homo sapiens | Janus kinase 2,JAK-2 |
| 3 | E, F (A, B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 2 | Chemie (TRS) | |||
| 4 | G, H, I (A, B, E) | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 297 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ala 181 | Asp 181 | engineered mutation |
| Ala 215 | Cys 215 | engineered mutation |
| Ala 262 | Gln 262 | engineered mutation |
| Ala 283 | Gly 283 | conflict |
| Ala 286 | Ser 286 | conflict |
| Ala 287 | Val 287 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 72632.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 244.3 | |
| All* | Total formula weight | 72876.8 |
