8EXM
Crystal structure of PTP1B D181A/Q262A phosphatase domain with a JAK3 activation loop phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 299 | 34733.6 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | B (D) | Tyrosine-protein kinase JAK3 activation loop peptide | polymer | 16 | 1907.2 | 1 | UniProt (P52333) | Homo sapiens | Janus kinase 3,JAK-3,Leukocyte janus kinase,L-JAK |
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 5 | E (A) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A: 1 - 299 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Glu 21 | Gln 21 | conflict |
| Ala 181 | Asp 181 | engineered mutation |
| Ala 262 | Gln 262 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36640.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 217.1 | |
| All* | Total formula weight | 36857.9 |
