8EXI
Crystal structure of apo PTP1B D181A/Q262A phosphatase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 298 | 34576.5 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B,PTP-1B |
| 2 | B (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | C (A) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A: 1 - 297 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Glu 61 | Gln 61 | conflict |
| Ala 181 | Asp 181 | engineered mutation |
| Ala 262 | Gln 262 | engineered mutation |
| Ala 298 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34576.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 195.2 | |
| All* | Total formula weight | 34771.7 |
