8EUQ
Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, F | HLA class II histocompatibility antigen, DR alpha chain | polymer | 188 | 21882.6 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) In PDB | Homo sapiens (human) | MHC class II antigen DRA |
2 | D, H | c44H10 Fab light chain | polymer | 214 | 23505.1 | 2 | Homo sapiens | ||
3 | B, G | Hemagglutinin HA1 chain,HLA class II histocompatibility antigen DR beta chain | polymer | 226 | 25935.8 | 2 | UniProt (P04664) UniProt (A0A1V1IGJ9) Pfam (PF00969) Pfam (PF07654) In PDB | Influenza A virus | MHC class II antigen |
4 | C, I | c44H10 Fab heavy chain | polymer | 223 | 23668.6 | 2 | Homo sapiens | ||
5 | E, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
6 | I, A, D, F, B... | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
7 | G, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, F: 3 - 181 (UniProt: P01903)
B, G: 3 - 17 (UniProt: P04664)
B, G: 30 - 219 (UniProt: A0A1V1IGJ9)
PDB | External Database | Details |
---|---|---|
Thr 182 | - | expression tag |
Ser 183 | - | expression tag |
Gly 184 | - | expression tag |
Glu 185 | - | expression tag |
Asn 186 | - | expression tag |
Leu 187 | - | expression tag |
Tyr 188 | - | expression tag |
Phe 189 | - | expression tag |
Gln 190 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 3 | Ala 304 | engineered mutation |
Ala 4 | Cys 305 | engineered mutation |
Ser 18 | - | linker |
Gly 19 | - | linker |
Gly 20 | - | linker |
Ser 21 | - | linker |
Gly 22 | - | linker |
Ser 23 | - | linker |
Ile 24 | - | linker |
Glu 25 | - | linker |
Gly 26 | - | linker |
Arg 27 | - | linker |
Gly 28 | - | linker |
Ser 29 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 220 | - | expression tag |
Gly 221 | - | expression tag |
Gly 222 | - | expression tag |
Glu 223 | - | expression tag |
Asn 224 | - | expression tag |
Leu 225 | - | expression tag |
Tyr 226 | - | expression tag |
Phe 227 | - | expression tag |
Gln 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 189984.1 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 1979.4 | |
All* | Total formula weight | 192812.3 |