8EUQ
Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, F) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 188 | 21882.6 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, D (D, H) | c44H10 Fab light chain | polymer | 214 | 23505.1 | 2 | Homo sapiens | ||
| 3 | E, G (B, G) | Hemagglutinin HA1 chain,HLA class II histocompatibility antigen DR beta chain | polymer | 226 | 25935.8 | 2 | UniProt (P04664) UniProt (A0A1V1IGJ9) Pfam (PF00969) Pfam (PF07654) | Influenza A virus | MHC class II antigen |
| 4 | F, H (C, I) | c44H10 Fab heavy chain | polymer | 223 | 23668.6 | 2 | Homo sapiens | ||
| 5 | I, J (E, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | BA, K, L, M, N... (I, A, D, F, B...) | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
| 7 | AA, U (G, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A, F: 3 - 181 (UniProt: P01903)
B, G: 3 - 17 (UniProt: P04664)
B, G: 30 - 219 (UniProt: A0A1V1IGJ9)
| PDB | External Database | Details |
|---|---|---|
| Thr 182 | - | expression tag |
| Ser 183 | - | expression tag |
| Gly 184 | - | expression tag |
| Glu 185 | - | expression tag |
| Asn 186 | - | expression tag |
| Leu 187 | - | expression tag |
| Tyr 188 | - | expression tag |
| Phe 189 | - | expression tag |
| Gln 190 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | Ala 304 | engineered mutation |
| Ala 4 | Cys 305 | engineered mutation |
| Ser 18 | - | linker |
| Gly 19 | - | linker |
| Gly 20 | - | linker |
| Ser 21 | - | linker |
| Gly 22 | - | linker |
| Ser 23 | - | linker |
| Ile 24 | - | linker |
| Glu 25 | - | linker |
| Gly 26 | - | linker |
| Arg 27 | - | linker |
| Gly 28 | - | linker |
| Ser 29 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 220 | - | expression tag |
| Gly 221 | - | expression tag |
| Gly 222 | - | expression tag |
| Glu 223 | - | expression tag |
| Asn 224 | - | expression tag |
| Leu 225 | - | expression tag |
| Tyr 226 | - | expression tag |
| Phe 227 | - | expression tag |
| Gln 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 189984.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1979.4 | |
| All* | Total formula weight | 192812.3 |
