8ESH
Structure of chimeric HLA-A*02:01 bound to CMV peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA-A*02:01 | polymer | 273 | 31651.8 | 1 | UniProt (D2KZ37) | Homo sapiens (human) | MHC class I antigen |
| 2 | B (B) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C (C) | CMV peptide | polymer | 9 | 1199.5 | 1 | Human betaherpesvirus 5 | ||
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A: 2 - 274 (UniProt: D2KZ37)
| PDB | External Database | Details |
|---|---|---|
| Asp 9 | Phe 8 | engineered mutation |
| Ser 24 | Ala 23 | engineered mutation |
| Arg 62 | Gly 61 | engineered mutation |
| Asn 63 | Glu 62 | engineered mutation |
| Ile 66 | Lys 65 | engineered mutation |
| Phe 67 | Val 66 | engineered mutation |
| Thr 69 | Ala 68 | engineered mutation |
| Asn 70 | His 69 | engineered mutation |
| Ser 77 | Asn 76 | engineered mutation |
| Asn 80 | Thr 79 | engineered mutation |
| Leu 95 | Val 94 | engineered mutation |
| Ser 97 | Arg 96 | engineered mutation |
| Asn 114 | His 113 | engineered mutation |
| Asn 116 | Tyr 115 | engineered mutation |
| Ile 142 | Thr 141 | engineered mutation |
| Asp 156 | Leu 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44599.4 | |
| All* | Total formula weight | 44599.4 |
