8ESF
Crystal structure of human Nischarin PX and LRR domains with engineered mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nischarin | polymer | 502 | 56393.2 | 2 | UniProt (Q9Y2I1) Pfam (PF00787) | Homo sapiens (human) | Imidazoline receptor 1,I-1,IR1,Imidazoline receptor antisera-selected protein,hIRAS,Imidazoline-1 receptor,I1R,Imidazoline-1 receptor candidate protein,I-1 receptor candidate protein,I1R candidate protein |
| 2 | C (A) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 468 (UniProt: Q9Y2I1)
| PDB | External Database | Details |
|---|---|---|
| Met -33 | - | expression tag |
| Gly -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Ser -30 | - | expression tag |
| His -29 | - | expression tag |
| His -28 | - | expression tag |
| His -27 | - | expression tag |
| His -26 | - | expression tag |
| His -25 | - | expression tag |
| His -24 | - | expression tag |
| Ser -23 | - | expression tag |
| Ser -22 | - | expression tag |
| Gly -21 | - | expression tag |
| Leu -20 | - | expression tag |
| Val -19 | - | expression tag |
| Pro -18 | - | expression tag |
| Arg -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| Met -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Met -10 | - | expression tag |
| Thr -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gln -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Met -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asn 29 | Thr 29 | conflict |
| Arg 38 | Thr 38 | conflict |
| Val 39 | Asp 39 | conflict |
| Lys 43 | Glu 43 | conflict |
| His 64 | Arg 64 | conflict |
| Arg 89 | Glu 89 | conflict |
| Tyr 102 | Ala 102 | conflict |
| Lys 119 | Phe 119 | conflict |
| Gln 127 | Ala 127 | conflict |
| Gln 142 | Gly 142 | conflict |
| Glu 148 | Ala 148 | conflict |
| Thr 150 | Gly 150 | conflict |
| Cys 184 | Thr 184 | conflict |
| Ile 192 | Val 192 | conflict |
| Gln 193 | Ser 193 | conflict |
| Ile 205 | Gln 205 | conflict |
| Gln 208 | Leu 208 | conflict |
| Arg 230 | Lys 230 | conflict |
| Tyr 233 | Arg 233 | conflict |
| Glu 236 | Val 236 | conflict |
| Thr 251 | Ala 251 | conflict |
| Cys 298 | Ser 298 | conflict |
| Ile 299 | Val 299 | variant |
| Cys 301 | Glu 301 | conflict |
| Glu 321 | Gly 321 | conflict |
| Thr 345 | Ser 345 | conflict |
| Ser 385 | Arg 385 | conflict |
| Asn 386 | Asp 386 | conflict |
| His 397 | Ser 397 | conflict |
| Tyr 406 | His 406 | conflict |
| Leu 407 | Val 407 | conflict |
| Thr 410 | Leu 410 | conflict |
| Val 414 | Leu 414 | conflict |
| Thr 415 | Ser 415 | conflict |
| Thr 416 | Ile 416 | conflict |
| Asp 430 | Glu 430 | conflict |
| Glu 440 | Thr 440 | conflict |
| Gln 444 | Glu 444 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112786.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 69.1 | |
| All* | Total formula weight | 112855.4 |
