8ER7
FKBP12-FRB in Complex with Compound 12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E | Peptidyl-prolyl cis-trans isomerase FKBP1A | polymer | 108 | 11923.6 | 3 | UniProt (P62942) Pfam (PF00254) In PDB | Homo sapiens (human) | PPIase FKBP1A,12 kDa FK506-binding protein,12 kDa FKBP,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase |
| 2 | B, D, F | non-specific serine/threonine protein kinase | polymer | 95 | 11389.0 | 3 | UniProt (B1AKP8) Pfam (PF08771) UniProt (by SIFTS) (P42345) In PDB | Homo sapiens (human) | |
| 3 | A, C, E | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-5,10,21-trimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone | non-polymer | 930.2 | 3 | Chemie (XZ3) | |||
| 4 | D, F | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, C, E: 2 - 108 (UniProt: P62942)
B, D, F: 2019 - 2112 (UniProt: B1AKP8)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 2018 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 69937.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2861.5 | |
| All* | Total formula weight | 72799.3 |
