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8EQ9

Co-crystal structure of PERK with compound 11

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(AAA)
Eukaryotic translation initiation factor 2-alpha kinase 3polymer31736816.41UniProt (Q9NZJ5)
Pfam (PF00069)
Homo sapiens (human)PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK
2B
(AAA)
(2R)-N-[(4M)-4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-3-methylphenyl]-2-(3-fluorophenyl)-2-hydroxyacetamidenon-polymer405.41Chemie (WPB)
3C
(AAA)
waterwater18.024Chemie (HOH)
Sequence modifications
AAA: 575 - 872 (UniProt: Q9NZJ5)
PDBExternal DatabaseDetails
Gly 573-expression tag
Ser 574-expression tag
AAA: 873 - 1094 (UniProt: Q9NZJ5)
PDBExternal DatabaseDetails
Asn 937Asp 937engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight36816.4
Non-Polymers*Number of molecules1
Total formula weight405.4
All*Total formula weight37221.8
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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