8EPK

Complex of anticoagulant RNA aptamer and human coagulation factor IXa (S195A)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Coagulation factor IXa light chain	polymer	65	7267.3	2	UniProt (P00740) Pfam (PF14670) In PDB	Homo sapiens (human)
2	B, D	Coagulation factor IXa heavy chain	polymer	235	26174.8	2	UniProt (P00740) Pfam (PF00089) In PDB	Homo sapiens (human)
3	E, F	RNA (31-MER)	polymer	31	10120.3	2		synthetic construct
4	B, D	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
5	E, F	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6		water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, C: 84 - 144 (UniProt: P00740)

PDB	External Database	Details
Arg 145	-	insertion
Arg 146	-	insertion
Lys 147	-	insertion
Arg 148	-	insertion

B, D: 16 - 245 (UniProt: P00740)

PDB	External Database	Details
Ala 195	Ser 411	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	87124.8
Non-Polymers*	Number of molecules	4
	Total formula weight	128.8
All*	Total formula weight	87253.6

*Water molecules are not included.