8EPK
Complex of anticoagulant RNA aptamer and human coagulation factor IXa (S195A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Coagulation factor IXa light chain | polymer | 65 | 7267.3 | 2 | UniProt (P00740) Pfam (PF14670) | Homo sapiens (human) | |
| 2 | B, D (B, D) | Coagulation factor IXa heavy chain | polymer | 235 | 26174.8 | 2 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | E, F (E, F) | RNA (31-MER) | polymer | 31 | 10120.3 | 2 | synthetic construct | ||
| 4 | G, H (B, D) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | I, J (E, F) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K, L, M, N (A, D, E, F) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, C: 84 - 144 (UniProt: P00740)
B, D: 16 - 245 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Arg 145 | - | insertion |
| Arg 146 | - | insertion |
| Lys 147 | - | insertion |
| Arg 148 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 87124.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 128.8 | |
| All* | Total formula weight | 87253.6 |
