8EME

EGFR(T790M/V948R) in complex with ZNL-0056

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Epidermal growth factor receptor	polymer	331	37724.6	2	UniProt (P00533) Pfam (PF07714) In PDB	Homo sapiens (human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2	B	N-{7-methyl-1-[(3S)-1-(prop-2-enoyl)azepan-3-yl]-1H-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide	non-polymer		477.6	1	Chemie (ZNL)

Sequence modifications

B, A: 695 - 1022 (UniProt: P00533)

PDB	External Database	Details
Gly 692	-	expression tag
Ser 693	-	expression tag
Thr 694	-	expression tag
Met 790	Thr 790	engineered mutation
Arg 948	Val 948	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75449.2
Non-Polymers*	Number of molecules	1
	Total formula weight	477.6
All*	Total formula weight	75926.8

*Water molecules are not included.