8EME
EGFR(T790M/V948R) in complex with ZNL-0056
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 2 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | B | N-{7-methyl-1-[(3S)-1-(prop-2-enoyl)azepan-3-yl]-1H-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide | non-polymer | 477.6 | 1 | Chemie (ZNL) |
Sequence modifications
B, A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ser 693 | - | expression tag |
Thr 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75449.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 477.6 | |
All* | Total formula weight | 75926.8 |