8EL1
Structure of MBP-Mcl-1 in complex with ABBV-467
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 532 | 59136.9 | 4 | UniProt (P0AEX9) UniProt (Q07820) Pfam (PF01547) Pfam (PF00452) | Escherichia coli | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
| 2 | E, F, G, H (E, F, G, H) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 4 | In PDB GlyTouCan (G07411ON) | |||
| 3 | I, J, K, L (A, B, C, D) | (7R,16R)-19,23-dichloro-10-{[2-(4-{[(2R)-1,4-dioxan-2-yl]methoxy}phenyl)pyrimidin-4-yl]methoxy}-1-(4-fluorophenyl)-20,22-dimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7,8,15,16-tetrahydro-18,21-etheno-13,9-(metheno)-6,14,17-trioxa-2-thia-3,5-diazacyclononadeca[1,2,3-cd]indene-7-carboxylic acid | non-polymer | 1038.0 | 4 | Chemie (WME) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -195 - 170 (UniProt: P0AEX9)
A, B, C, D: 173 - 321 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Met -210 | - | initiating methionine |
| Ala -209 | - | expression tag |
| His -208 | - | expression tag |
| His -207 | - | expression tag |
| His -206 | - | expression tag |
| His -205 | - | expression tag |
| His -204 | - | expression tag |
| His -203 | - | expression tag |
| Glu -202 | - | expression tag |
| Asn -201 | - | expression tag |
| Leu -200 | - | expression tag |
| Tyr -199 | - | expression tag |
| Phe -198 | - | expression tag |
| Gln -197 | - | expression tag |
| Gly -196 | - | expression tag |
| Gly 171 | - | linker |
| Ser 172 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 194 | Lys 194 | engineered mutation |
| Ala 197 | Lys 197 | engineered mutation |
| Ala 201 | Arg 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 236547.5 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1369.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 4151.9 | |
| All* | Total formula weight | 242068.6 |
