8EJJ
Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Glycoprotein GP1 | polymer | 197 | 22199.1 | 3 | UniProt (Q6GWS0) Pfam (PF00798) UniProt (by SIFTS) (P08669) | Lassa mammarenavirus | |
| 2 | D, E, K (H, I, h) | S370.7 heavy chain Fab | polymer | 128 | 14109.7 | 3 | Homo sapiens (Human) | ||
| 3 | F, G, L (J, L, l) | S370.7 light chain Fab | polymer | 107 | 11517.6 | 3 | Homo sapiens (Human) | ||
| 4 | H, I, J (a, b, c) | Glycoprotein GP2 | polymer | 164 | 19146.8 | 3 | UniProt (Q6GWS0) Pfam (PF00798) UniProt (by SIFTS) (P08669) | Lassa mammarenavirus | Pre-GP-C |
| 5 | M (D) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 6 | AA, CA, DA, GA, JA... (V, X, Y, e, i...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 15 | In PDB GlyTouCan (G42666HT) | |||
| 7 | BA, P, V (W, G, Q) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 8 | S, Y (N, T) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 9 | EA, HA, KA (Z, f, j) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G56014GC) | |||
| 10 | FA, IA, LA (d, g, k) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 11 | NA, OA, PA, QA, RA... (A, B, C, a, b...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 12 | TA (l) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) |
Sequence modifications
A, B, C: 59 - 255 (UniProt: Q6GWS0)
a, b, c: 260 - 423 (UniProt: Q6GWS0)
| PDB | External Database | Details |
|---|---|---|
| Cys 207 | Arg 207 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Pro 329 | Glu 329 | engineered mutation |
| Cys 360 | Gly 360 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 200919.6 | |
| Branched | Number of molecules | 27 |
| Total formula weight | 15626.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1507.4 | |
| All* | Total formula weight | 218053.5 |
