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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8EJH

Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, D
(C, B, A)		Glycoprotein G1polymer25929098.43UniProt (P08669)
Pfam (PF00798)		Lassa mammarenavirusPre-GP-C
2C, E, F
(c, b, a)		Glycoprotein G2polymer40644765.03UniProt (P08669)
Pfam (PF00798)		Lassa mammarenavirusGP2
3G, I, K
(H, J, h)		12.1F Fab heavy chainpolymer12413650.23Homo sapiens
4H, J, L
(L, K, l)		12.1F Fab light chainpolymer10811851.23Homo sapiens
5CA, FA, HA, IA, M...
(X, d, f, g, D...)		beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.512In PDB
GlyTouCan (G15407YE)
6DA, N, U
(Y, E, P)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched910.83In PDB
GlyTouCan (G10756ZZ)
7BA, EA, GA, KA, MA...
(W, Z, e, j, m...)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.49In PDB
GlyTouCan (G42666HT)
8AA, JA, LA
(V, i, k)		alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1235.13In PDB
GlyTouCan (G07617FP)
9NA, OA, PA, QA, RA...
(c, b, a)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.26Chemie (NAG)
10TA, UA, VA
(H, J, h)		alpha-D-mannopyranosenon-polymer180.23Chemie (MAN)
Sequence modifications
C, B, A: 1 - 259 (UniProt: P08669)
PDBExternal DatabaseDetails
Cys 207Arg 207engineered mutation
Arg 258Leu 258engineered mutation
Arg 259Leu 259engineered mutation
c, b, a: 260 - 424 (UniProt: P08669)
PDBExternal DatabaseDetails
Pro 329Glu 329engineered mutation
Cys 360Gly 360engineered mutation
Gly 425-expression tag
Ser 426-expression tag
Gly 427-expression tag
Gly 428-expression tag
Ser 429-expression tag
Gly 430-expression tag
Gly 431-expression tag
Ser 432-expression tag
Gly 433-expression tag
Gly 434-expression tag
Ser 435-expression tag
Gly 436-expression tag
Gly 437-expression tag
Ser 438-expression tag
Glu 439-expression tag
Lys 440-expression tag
Ala 441-expression tag
Ala 442-expression tag
Lys 443-expression tag
Ala 444-expression tag
Glu 445-expression tag
Glu 446-expression tag
Ala 447-expression tag
Ala 448-expression tag
Arg 449-expression tag
Lys 450-expression tag
Met 451-expression tag
Glu 452-expression tag
Glu 453-expression tag
Leu 454-expression tag
Phe 455-expression tag
Lys 456-expression tag
Lys 457-expression tag
His 458-expression tag
Lys 459-expression tag
Ile 460-expression tag
Val 461-expression tag
Ala 462-expression tag
Val 463-expression tag
Leu 464-expression tag
Arg 465-expression tag
Ala 466-expression tag
Asn 467-expression tag
Ser 468-expression tag
Val 469-expression tag
Glu 470-expression tag
Glu 471-expression tag
Ala 472-expression tag
Ile 473-expression tag
Glu 474-expression tag
Lys 475-expression tag
Ala 476-expression tag
Val 477-expression tag
Ala 478-expression tag
Val 479-expression tag
Phe 480-expression tag
Ala 481-expression tag
Gly 482-expression tag
Gly 483-expression tag
Val 484-expression tag
His 485-expression tag
Leu 486-expression tag
Ile 487-expression tag
Glu 488-expression tag
Ile 489-expression tag
Thr 490-expression tag
Phe 491-expression tag
Thr 492-expression tag
Val 493-expression tag
Pro 494-expression tag
Asp 495-expression tag
Ala 496-expression tag
Asp 497-expression tag
Thr 498-expression tag
Val 499-expression tag
Ile 500-expression tag
Lys 501-expression tag
Ala 502-expression tag
Leu 503-expression tag
Ser 504-expression tag
Val 505-expression tag
Leu 506-expression tag
Lys 507-expression tag
Glu 508-expression tag
Lys 509-expression tag
Gly 510-expression tag
Ala 511-expression tag
Ile 512-expression tag
Ile 513-expression tag
Gly 514-expression tag
Ala 515-expression tag
Gly 516-expression tag
Thr 517-expression tag
Val 518-expression tag
Thr 519-expression tag
Ser 520-expression tag
Val 521-expression tag
Glu 522-expression tag
Gln 523-expression tag
Cys 524-expression tag
Arg 525-expression tag
Lys 526-expression tag
Ala 527-expression tag
Val 528-expression tag
Glu 529-expression tag
Ser 530-expression tag
Gly 531-expression tag
Ala 532-expression tag
Glu 533-expression tag
Phe 534-expression tag
Ile 535-expression tag
Val 536-expression tag
Ser 537-expression tag
Pro 538-expression tag
His 539-expression tag
Leu 540-expression tag
Asp 541-expression tag
Glu 542-expression tag
Glu 543-expression tag
Ile 544-expression tag
Ser 545-expression tag
Gln 546-expression tag
Phe 547-expression tag
Cys 548-expression tag
Lys 549-expression tag
Glu 550-expression tag
Lys 551-expression tag
Gly 552-expression tag
Val 553-expression tag
Phe 554-expression tag
Tyr 555-expression tag
Met 556-expression tag
Pro 557-expression tag
Gly 558-expression tag
Val 559-expression tag
Met 560-expression tag
Thr 561-expression tag
Pro 562-expression tag
Thr 563-expression tag
Glu 564-expression tag
Leu 565-expression tag
Val 566-expression tag
Lys 567-expression tag
Ala 568-expression tag
Met 569-expression tag
Lys 570-expression tag
Leu 571-expression tag
Gly 572-expression tag
His 573-expression tag
Asp 574-expression tag
Ile 575-expression tag
Leu 576-expression tag
Lys 577-expression tag
Leu 578-expression tag
Phe 579-expression tag
Pro 580-expression tag
Gly 581-expression tag
Glu 582-expression tag
Val 583-expression tag
Val 584-expression tag
Gly 585-expression tag
Pro 586-expression tag
Glu 587-expression tag
Phe 588-expression tag
Val 589-expression tag
Lys 590-expression tag
Ala 591-expression tag
Met 592-expression tag
Lys 593-expression tag
Gly 594-expression tag
Pro 595-expression tag
Phe 596-expression tag
Pro 597-expression tag
Asn 598-expression tag
Val 599-expression tag
Lys 600-expression tag
Phe 601-expression tag
Val 602-expression tag
Pro 603-expression tag
Thr 604-expression tag
Gly 605-expression tag
Gly 606-expression tag
Val 607-expression tag
Asp 608-expression tag
Leu 609-expression tag
Asp 610-expression tag
Asn 611-expression tag
Val 612-expression tag
Cys 613-expression tag
Glu 614-expression tag
Trp 615-expression tag
Phe 616-expression tag
Asp 617-expression tag
Ala 618-expression tag
Gly 619-expression tag
Val 620-expression tag
Leu 621-expression tag
Ala 622-expression tag
Val 623-expression tag
Gly 624-expression tag
Val 625-expression tag
Gly 626-expression tag
Asp 627-expression tag
Ala 628-expression tag
Leu 629-expression tag
Val 630-expression tag
Glu 631-expression tag
Gly 632-expression tag
Asp 633-expression tag
Pro 634-expression tag
Asp 635-expression tag
Glu 636-expression tag
Val 637-expression tag
Arg 638-expression tag
Glu 639-expression tag
Lys 640-expression tag
Ala 641-expression tag
Lys 642-expression tag
Glu 643-expression tag
Phe 644-expression tag
Val 645-expression tag
Glu 646-expression tag
Lys 647-expression tag
Ile 648-expression tag
Arg 649-expression tag
Gly 650-expression tag
Cys 651-expression tag
Thr 652-expression tag
Glu 653-expression tag
Gly 654-expression tag
Ser 655-expression tag
Leu 656-expression tag
Glu 657-expression tag
Trp 658-expression tag
Ser 659-expression tag
His 660-expression tag
Pro 661-expression tag
Gln 662-expression tag
Phe 663-expression tag
Glu 664-expression tag
Lys 665-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains12
Total formula weight298094.4
BranchedNumber of molecules27
Total formula weight17295.9
Non-Polymers*Number of molecules9
Total formula weight1867.7
All*Total formula weight317258.0
*Water molecules are not included.

244349

PDB entries from 2025-11-05

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