8EHM

Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144F Mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	3C-like proteinase nsp5	polymer	306	33885.6	2	UniProt (P0DTD1) Pfam (PF05409)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)	3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5
2	C, D (A, B)	water	water		18.0	293	Chemie (HOH)

Sequence modifications

A, B: 1 - 306 (UniProt: P0DTD1)

PDB	External Database	Details
Phe 144	Ser 3407	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67771.3
All*	Total formula weight	67771.3

*Water molecules are not included.