8EGM

Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with compound AZ13644908

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	UDP-N-acetylmuramate--L-alanine ligase	polymer	316	33976.6	8	UniProt (Q9HW02) Pfam (PF01225) Pfam (PF08245) In PDB	Pseudomonas aeruginosa PAO1	UDP-N-acetylmuramoyl-L-alanine synthetase
2	A, B, C, D, E...	(2R)-2-({4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)-2-phenylethyl (2-aminoethyl)carbamate	non-polymer		492.6	8	Chemie (WIU)
3	A, B, C, D, E...	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
4		water	water		18.0	881	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 16 - 322 (UniProt: Q9HW02)

PDB	External Database	Details
Met 7	-	initiating methionine
Ala 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
Met 15	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	271813.2
Non-Polymers*	Number of molecules	16
	Total formula weight	4709.1
All*	Total formula weight	276522.3

*Water molecules are not included.