8EGM
Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with compound AZ13644908
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | UDP-N-acetylmuramate--L-alanine ligase | polymer | 316 | 33976.6 | 8 | UniProt (Q9HW02) Pfam (PF01225) Pfam (PF08245) | Pseudomonas aeruginosa PAO1 | UDP-N-acetylmuramoyl-L-alanine synthetase |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | (2R)-2-({4-[(5-tert-butyl-1-methyl-1H-pyrazol-3-yl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}amino)-2-phenylethyl (2-aminoethyl)carbamate | non-polymer | 492.6 | 8 | Chemie (WIU) | |||
| 3 | J, L, N, P, R... (A, B, C, D, E...) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 4 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 881 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 16 - 322 (UniProt: Q9HW02)
| PDB | External Database | Details |
|---|---|---|
| Met 7 | - | initiating methionine |
| Ala 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| Met 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 271813.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 4709.1 | |
| All* | Total formula weight | 276522.3 |
