8EG6
huCaspase-6 in complex with inhibitor 2a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Caspase-6 subunit p18 | polymer | 150 | 17301.9 | 4 | UniProt (P55212) Pfam (PF00656) | Homo sapiens (human) | Caspase-6 subunit p20 |
| 2 | B, D, F, H (B, D, F, H) | Caspase-6 subunit p11 | polymer | 109 | 12502.4 | 4 | UniProt (P55212) Pfam (PF00656) | Homo sapiens (human) | Caspase-6 subunit p10 |
| 3 | I, M, R, S, Y (A, B, E, G) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 4 | BA, CA, J, K, N... (H, A, B, D, E...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 5 | AA, L, O, W (H, B, D, F) | (3R)-1-(ethanesulfonyl)-N-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxamide | non-polymer | 380.4 | 4 | Chemie (US9) | |||
| 6 | V (E) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 7 | DA, EA, FA, GA, HA... (A, B, C, D, E...) | water | water | 18.0 | 920 | Chemie (HOH) |
Sequence modifications
B, D, F, H: 194 - 293 (UniProt: P55212)
| PDB | External Database | Details |
|---|---|---|
| Met 193 | - | initiating methionine |
| Leu 294 | - | expression tag |
| Glu 295 | - | expression tag |
| His 296 | - | expression tag |
| His 297 | - | expression tag |
| His 298 | - | expression tag |
| His 299 | - | expression tag |
| His 300 | - | expression tag |
| His 301 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 119217.0 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 2487.7 | |
| All* | Total formula weight | 121704.7 |
