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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8EF6

Morphine-bound mu-opioid receptor-Gi complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, F
(R, M)		Mu-type opioid receptorpolymer36741072.22UniProt (P35372)
Pfam (PF00001)		Homo sapiens (human)M-OR-1,MOR-1,Mu opiate receptor,Mu opioid receptor,MOP,hMOP
2B, G
(A, F)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440445.12UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
3C
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer35339020.71UniProt (P54311)
Pfam (PF25391)		Rattus norvegicus (Rat)Transducin beta chain 1
4D
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer687563.81UniProt (P63212)
Pfam (PF00631)		Bos taurus (cattle)G gamma-I
5E
(E)		scFV16polymer24826408.51synthetic construct
6H, N
(R, M)		(7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOLnon-polymer285.32Chemie (MOI)
PubChem (4253)
PubChem (5980)
PubChem (356194)
PubChem (5288826)
PubChem (5319899)
PubChem (5324287)
PubChem (5359251)
PubChem (5479215)
PubChem (5491823)
PubChem (5493069)
PubChem (5702292)
PubChem (9795834)
PubChem (9917779)
PubChem (9951040)
PubChem (10016785)
PubChem (11969702)
PubChem (15560000)
PubChem (16219646)
PubChem (21158839)
PubChem (23423979)
PubChem (23424011)
PubChem (25024027)
PubChem (44246528)
PubChem (44246529)
PubChem (44458320)
PubChem (44577290)
PubChem (49823836)
PubChem (44273167)
PubChem (44283013)
PubChem (86270850)
PubChem (5462237)
PubChem (54589135)
PubChem (124524994)
PubChem (11161935)
PubChem (57733958)
PubChem (58905556)
PubChem (59666902)
PubChem (138972221)
PubChem (59913787)
PubChem (60052703)
PubChem (60053788)
PubChem (70971412)
PubChem (89991131)
PubChem (99645414)
PubChem (124585334)
PubChem (124670558)
PubChem (126683383)
PubChem (126968565)
PubChem (153648174)
PubChem (162879090)
PubChem (162879091)
PubChem (162879092)
PubChem (162879093)
7I, J, K, L, M...
(R, M)		CHOLESTEROLnon-polymer386.710Chemie (CLR)
PubChem (304)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (638019)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (16219173)
PubChem (16758052)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (176980071)
PubChem (45044259)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (49853509)
PubChem (44654663)
PubChem (46937002)
PubChem (59274407)
PubChem (50990013)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (52934537)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (56621683)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (57915018)
PubChem (57939063)
PubChem (138967089)
PubChem (58428240)
PubChem (58445498)
PubChem (139566851)
PubChem (58663286)
PubChem (15939944)
PubChem (59450329)
PubChem (59628412)
PubChem (171828367)
PubChem (173516975)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
Sequence modifications
A, F: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Ala 203Gly 203conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Met -12-expression tag
His -11-expression tag
His -10-expression tag
His -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Leu -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains7
Total formula weight236027.4
Non-Polymers*Number of molecules12
Total formula weight4437.2
All*Total formula weight240464.6
*Water molecules are not included.

251801

PDB entries from 2026-04-08

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