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8ED9

cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, C, E, G
(A, B, C, D)
Transient receptor potential cation channel, subfamily M, member 3polymer1343154649.34UniProt (Q5F4S7)
Pfam (PF18139)
Pfam (PF00520)
Pfam (PF16519)
UniProt (by SIFTS) (J9SQF3)
Mus musculus (house mouse)
2B, D, F, H
(E, F, G, H)
Unidentified segment at the N-terminus of TRPM3polymer171464.84Mus musculus
3I, L, P, S
(A, B, C, D)
1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATEnon-polymer705.04Chemie (3PH)
4J, M, Q, T
(A, B, C, D)
(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-ennon-polymer544.84Chemie (9Z9)
5K, N, R, U
(A, B, C, D)
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoatenon-polymer746.64Chemie (PIO)
6O
(B)
SODIUM IONnon-polymer23.01Chemie (NA)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight624456.5
Non-Polymers*Number of molecules13
Total formula weight8008.5
All*Total formula weight632465.0
*Water molecules are not included.

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PDB entries from 2025-06-18

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