8EBY

XPC release from Core7-XPA-DNA (AP)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TFIIH basal transcription factor complex helicase XPB subunit	polymer	782	89404.7	1	UniProt (P19447) Pfam (PF13625) Pfam (PF04851) Pfam (PF16203) In PDB	Homo sapiens (human)	Basic transcription factor 2 89 kDa subunit, BTF2 p89, DNA excision repair protein ERCC-3, DNA repair protein complementing XP-B cells, TFIIH basal transcription factor complex 89 kDa subunit, TFIIH p89, Xeroderma pigmentosum group B-complementing protein
2	B	General transcription and DNA repair factor IIH helicase subunit XPD	polymer	768	88018.0	1	UniProt (P18074) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) In PDB	Homo sapiens (human)	TFIIH subunit XPD,Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein
3	C	General transcription factor IIH subunit 1	polymer	548	62116.5	1	UniProt (P32780) Pfam (PF08567) Pfam (PF03909) In PDB	Homo sapiens (human)	Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,TFIIH basal transcription factor complex p62 subunit
4	D	General transcription factor IIH subunit 4, p52	polymer	462	52245.2	1	UniProt (Q92759) Pfam (PF18307) Pfam (PF03849) In PDB	Homo sapiens (human)	Basic transcription factor 2 52 kDa subunit, BTF2 p52, General transcription factor IIH polypeptide 4, TFIIH basal transcription factor complex p52 subunit
5	E	General transcription factor IIH subunit 2	polymer	417	46926.6	1	UniProt (Q13888) Pfam (PF04056) Pfam (PF07975) In PDB	Homo sapiens (human)	Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit
6	F	General transcription factor IIH subunit 3	polymer	308	34416.0	1	UniProt (Q13889) Pfam (PF03850) In PDB	Homo sapiens (human)	p34, Basic transcription factor 2 44 kDa subunit, BTF2 p44, General transcription factor IIH polypeptide 2, TFIIH basal transcription factor complex p44 subunit
7	G	General transcription factor IIH subunit 5	polymer	71	8060.4	1	UniProt (Q6ZYL4) Pfam (PF06331) In PDB	Homo sapiens (human)	General transcription factor IIH polypeptide 5, TFB5 ortholog, TFIIH basal transcription factor complex TTD-A subunit
8	H	DNA repair protein complementing XP-C cells	polymer	950	107437.6	1	UniProt (A0A024R2M8) Pfam (PF03835) Pfam (PF10403) Pfam (PF10404) Pfam (PF10405) UniProt (by SIFTS) (Q01831) In PDB	Homo sapiens (human)
9	K	DNA repair protein complementing XP-A cells	polymer	273	31422.1	1	UniProt (P23025) Pfam (PF01286) Pfam (PF05181) In PDB	Homo sapiens (human)	Xeroderma pigmentosum group A-complementing protein
10	L	DNA	polymer	23	7096.6	1		synthetic construct
11	M	DNA	polymer	22	6712.3	1		synthetic construct
12	B	IRON/SULFUR CLUSTER	non-polymer		351.6	1	Chemie (SF4)
13	E, F, K	ZINC ION	non-polymer		65.4	6	Chemie (ZN)

Sequence modifications

B: 1 - 760 (UniProt: P18074)

PDB	External Database	Details
Asp 761	-	expression tag
Tyr 762	-	expression tag
Lys 763	-	expression tag
Asp 764	-	expression tag
Asp 765	-	expression tag
Asp 766	-	expression tag
Asp 767	-	expression tag
Lys 768	-	expression tag

E: 1 - 395 (UniProt: Q13888)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Leu -8	-	expression tag
Glu -7	-	expression tag
Val -6	-	expression tag
Leu -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Pro -1	-	expression tag
His 0	-	expression tag

H: 1 - 940 (UniProt: A0A024R2M8)

PDB	External Database	Details
Met -9	-	initiating methionine
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
His 0	-	expression tag
Val 499	Ala 499	conflict

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	533856.1
Non-Polymers*	Number of molecules	7
	Total formula weight	744.1
All*	Total formula weight	534600.2

*Water molecules are not included.