8E9Z
CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Muscarinic acetylcholine receptor M3 | polymer | 568 | 62966.6 | 1 | UniProt (P20309) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (B) | miniGq | polymer | 246 | 28084.8 | 1 | Homo sapiens | ||
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 368 | 39798.4 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | scFv16 | polymer | 251 | 26679.7 | 1 | Mus musculus | ||
| 6 | F (A) | 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium | non-polymer | 197.3 | 1 | Chemie (IXO) | |||
| 7 | G (A) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) |
Sequence modifications
A: 46 - 463 (UniProt: P20309)
A: 464 - 590 (UniProt: P20309)
C: 2 - 340 (UniProt: P62873)
A: 464 - 590 (UniProt: P20309)
| PDB | External Database | Details |
|---|---|---|
| Gly 591 | - | expression tag |
| Gly 592 | - | expression tag |
| Ser 593 | - | expression tag |
| Gly 594 | - | expression tag |
| Gly 595 | - | expression tag |
| Gly 596 | - | expression tag |
| Gly 597 | - | expression tag |
| Ser 598 | - | expression tag |
| Gly 599 | - | expression tag |
| Gly 600 | - | expression tag |
| Ser 601 | - | expression tag |
| Ser 602 | - | expression tag |
| Ser 603 | - | expression tag |
| Gly 604 | - | expression tag |
| Gly 605 | - | expression tag |
| Gly 606 | - | expression tag |
| Gly 607 | - | expression tag |
| Ser 608 | - | expression tag |
| Gly 609 | - | expression tag |
| Gly 610 | - | expression tag |
| Gly 611 | - | expression tag |
| Gly 612 | - | expression tag |
| Ser 613 | - | expression tag |
| Gly 614 | - | expression tag |
| Gly 615 | - | expression tag |
| Ser 616 | - | expression tag |
| Ser 617 | - | expression tag |
| Ser 618 | - | expression tag |
| Gly 619 | - | expression tag |
| Gly 620 | - | expression tag |
| Val 621 | - | expression tag |
| Phe 622 | - | expression tag |
| Thr 623 | - | expression tag |
| Leu 624 | - | expression tag |
| Glu 625 | - | expression tag |
| Asp 626 | - | expression tag |
| Phe 627 | - | expression tag |
| Val 628 | - | expression tag |
| Gly 629 | - | expression tag |
| Asp 630 | - | expression tag |
| Trp 631 | - | expression tag |
| Glu 632 | - | expression tag |
| Gln 633 | - | expression tag |
| Thr 634 | - | expression tag |
| Ala 635 | - | expression tag |
| Ala 636 | - | expression tag |
| Tyr 637 | - | expression tag |
| Asn 638 | - | expression tag |
| Leu 639 | - | expression tag |
| Asp 640 | - | expression tag |
| Gln 641 | - | expression tag |
| Val 642 | - | expression tag |
| Leu 643 | - | expression tag |
| Glu 644 | - | expression tag |
| Gln 645 | - | expression tag |
| Gly 646 | - | expression tag |
| Gly 647 | - | expression tag |
| Val 648 | - | expression tag |
| Ser 649 | - | expression tag |
| Ser 650 | - | expression tag |
| Leu 651 | - | expression tag |
| Leu 652 | - | expression tag |
| Gln 653 | - | expression tag |
| Asn 654 | - | expression tag |
| Leu 655 | - | expression tag |
| Ala 656 | - | expression tag |
| Val 657 | - | expression tag |
| Ser 658 | - | expression tag |
| Val 659 | - | expression tag |
| Thr 660 | - | expression tag |
| Pro 661 | - | expression tag |
| Ile 662 | - | expression tag |
| Gln 663 | - | expression tag |
| Arg 664 | - | expression tag |
| Ile 665 | - | expression tag |
| Val 666 | - | expression tag |
| Arg 667 | - | expression tag |
| Ser 668 | - | expression tag |
| Gly 669 | - | expression tag |
| Glu 670 | - | expression tag |
| Asn 671 | - | expression tag |
| Ala 672 | - | expression tag |
| Leu 673 | - | expression tag |
| Lys 674 | - | expression tag |
| Ile 675 | - | expression tag |
| Asp 676 | - | expression tag |
| Ile 677 | - | expression tag |
| His 678 | - | expression tag |
| Val 679 | - | expression tag |
| Ile 680 | - | expression tag |
| Ile 681 | - | expression tag |
| Pro 682 | - | expression tag |
| Tyr 683 | - | expression tag |
| Glu 684 | - | expression tag |
| Gly 685 | - | expression tag |
| Leu 686 | - | expression tag |
| Ser 687 | - | expression tag |
| Ala 688 | - | expression tag |
| Asp 689 | - | expression tag |
| Gln 690 | - | expression tag |
| Met 691 | - | expression tag |
| Ala 692 | - | expression tag |
| Gln 693 | - | expression tag |
| Ile 694 | - | expression tag |
| Glu 695 | - | expression tag |
| Glu 696 | - | expression tag |
| Val 697 | - | expression tag |
| Phe 698 | - | expression tag |
| Lys 699 | - | expression tag |
| Val 700 | - | expression tag |
| Val 701 | - | expression tag |
| Tyr 702 | - | expression tag |
| Pro 703 | - | expression tag |
| Val 704 | - | expression tag |
| Asp 705 | - | expression tag |
| Asp 706 | - | expression tag |
| His 707 | - | expression tag |
| His 708 | - | expression tag |
| Phe 709 | - | expression tag |
| Lys 710 | - | expression tag |
| Val 711 | - | expression tag |
| Ile 712 | - | expression tag |
| Leu 713 | - | expression tag |
| Pro 714 | - | expression tag |
| Tyr 715 | - | expression tag |
| Gly 716 | - | expression tag |
| Thr 717 | - | expression tag |
| Leu 718 | - | expression tag |
| Val 719 | - | expression tag |
| Ile 720 | - | expression tag |
| Asp 721 | - | expression tag |
| Gly 722 | - | expression tag |
| Val 723 | - | expression tag |
| Thr 724 | - | expression tag |
| Pro 725 | - | expression tag |
| Asn 726 | - | expression tag |
| Met 727 | - | expression tag |
| Leu 728 | - | expression tag |
| Asn 729 | - | expression tag |
| Tyr 730 | - | expression tag |
| Phe 731 | - | expression tag |
| Gly 732 | - | expression tag |
| Arg 733 | - | expression tag |
| Pro 734 | - | expression tag |
| Tyr 735 | - | expression tag |
| Glu 736 | - | expression tag |
| Gly 737 | - | expression tag |
| Ile 738 | - | expression tag |
| Ala 739 | - | expression tag |
| Val 740 | - | expression tag |
| Phe 741 | - | expression tag |
| Asp 742 | - | expression tag |
| Gly 743 | - | expression tag |
| Lys 744 | - | expression tag |
| Lys 745 | - | expression tag |
| Ile 746 | - | expression tag |
| Thr 747 | - | expression tag |
| Val 748 | - | expression tag |
| Thr 749 | - | expression tag |
| Gly 750 | - | expression tag |
| Thr 751 | - | expression tag |
| Leu 752 | - | expression tag |
| Trp 753 | - | expression tag |
| Asn 754 | - | expression tag |
| Gly 755 | - | expression tag |
| Asn 756 | - | expression tag |
| Lys 757 | - | expression tag |
| Ile 758 | - | expression tag |
| Ile 759 | - | expression tag |
| Asp 760 | - | expression tag |
| Glu 761 | - | expression tag |
| Arg 762 | - | expression tag |
| Leu 763 | - | expression tag |
| Ile 764 | - | expression tag |
| Thr 765 | - | expression tag |
| Pro 766 | - | expression tag |
| Asp 767 | - | expression tag |
| Gly 768 | - | expression tag |
| Ser 769 | - | expression tag |
| Met 770 | - | expression tag |
| Leu 771 | - | expression tag |
| Phe 772 | - | expression tag |
| Arg 773 | - | expression tag |
| Val 774 | - | expression tag |
| Thr 775 | - | expression tag |
| Ile 776 | - | expression tag |
| Asn 777 | - | expression tag |
| Ser 778 | - | expression tag |
| Gly 779 | - | expression tag |
| Gly 780 | - | expression tag |
| Ser 781 | - | expression tag |
| Gly 782 | - | expression tag |
| Gly 783 | - | expression tag |
| His 784 | - | expression tag |
| His 785 | - | expression tag |
| His 786 | - | expression tag |
| His 787 | - | expression tag |
| His 788 | - | expression tag |
| His 789 | - | expression tag |
| His 790 | - | expression tag |
| His 791 | - | expression tag |
| His 792 | - | expression tag |
| His 793 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Gly 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Ser 351 | - | expression tag |
| Ser 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
| Gly 367 | - | expression tag |
| Gly 368 | - | expression tag |
| Ser 369 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 165390.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 684.0 | |
| All* | Total formula weight | 166074.7 |
