8E9W
CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Muscarinic acetylcholine receptor M3 | polymer | 365 | 41590.0 | 1 | UniProt (P20309) Pfam (PF00001) | Homo sapiens (human) | |
| 2 | B (B) | miniGq | polymer | 246 | 28084.8 | 1 | Homo sapiens | ||
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | scFv16 | polymer | 251 | 26679.7 | 1 | Mus musculus | ||
| 6 | F (A) | 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine | non-polymer | 292.4 | 1 | Chemie (WEC) |
Sequence modifications
A: 46 - 463 (UniProt: P20309)
A: 464 - 590 (UniProt: P20309)
| PDB | External Database | Details |
|---|---|---|
| Cys 149 | Tyr 149 | engineered mutation |
| Gly 239 | Ala 239 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 141501.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 292.4 | |
| All* | Total formula weight | 141793.8 |
