8E24
Human DNA polymerase theta in complex with allosteric inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | DNA polymerase theta | polymer | 668 | 75200.1 | 2 | UniProt (O75417) Pfam (PF00476) In PDB | Homo sapiens (human) | DNA polymerase eta |
2 | B, E | DNA | polymer | 17 | 5157.4 | 2 | synthetic construct | ||
3 | C, F | DNA | polymer | 13 | 3998.6 | 2 | synthetic construct | ||
4 | A, D | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A, D | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 491.2 | 2 | Chemie (DG3) | |||
6 | A, D | 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide | non-polymer | 463.4 | 2 | Chemie (UA6) | |||
7 | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A, D: 1818 - 2590 (UniProt: O75417)
PDB | External Database | Details |
---|---|---|
Gly 1817 | - | expression tag |
- | Ala 1868 | deletion |
- | Thr 1869 | deletion |
- | Ile 1870 | deletion |
- | Gly 1871 | deletion |
- | Ser 1872 | deletion |
- | Arg 1873 | deletion |
- | Phe 1874 | deletion |
- | Lys 1875 | deletion |
- | Gln 1876 | deletion |
- | Ala 1877 | deletion |
- | Ser 1878 | deletion |
- | Ser 1879 | deletion |
- | Pro 1880 | deletion |
- | Gln 1881 | deletion |
- | Glu 1882 | deletion |
- | Ile 1883 | deletion |
- | Pro 1884 | deletion |
- | Ile 1885 | deletion |
- | Arg 1886 | deletion |
- | Asp 1887 | deletion |
- | Asp 1888 | deletion |
- | Gln 1921 | deletion |
- | Lys 1922 | deletion |
- | His 1923 | deletion |
- | Ser 1924 | deletion |
- | Glu 1925 | deletion |
- | Ile 1926 | deletion |
- | Ser 1927 | deletion |
- | Ala 1928 | deletion |
- | Ser 1929 | deletion |
- | Leu 1930 | deletion |
- | Val 1931 | deletion |
- | Pro 1932 | deletion |
- | Pro 1933 | deletion |
- | Met 2149 | deletion |
- | Lys 2150 | deletion |
- | Asn 2151 | deletion |
- | Gln 2152 | deletion |
- | Gly 2153 | deletion |
- | Ser 2154 | deletion |
- | Lys 2155 | deletion |
- | Lys 2156 | deletion |
- | Thr 2157 | deletion |
- | Leu 2158 | deletion |
- | Gly 2159 | deletion |
- | Ser 2160 | deletion |
- | Thr 2161 | deletion |
- | Arg 2162 | deletion |
- | Arg 2163 | deletion |
- | Gly 2164 | deletion |
- | Ile 2165 | deletion |
- | Asp 2166 | deletion |
- | Asn 2167 | deletion |
- | Gly 2168 | deletion |
- | Arg 2169 | deletion |
- | Lys 2170 | deletion |
- | Leu 2171 | deletion |
- | Arg 2172 | deletion |
- | Val 2264 | deletion |
- | Gly 2265 | deletion |
- | Glu 2266 | deletion |
- | Ser 2267 | deletion |
- | Pro 2268 | deletion |
- | Pro 2269 | deletion |
- | Ser 2270 | deletion |
- | Gln 2271 | deletion |
- | Ala 2272 | deletion |
- | Val 2273 | deletion |
- | Gly 2274 | deletion |
- | Lys 2275 | deletion |
- | Gly 2276 | deletion |
- | Leu 2277 | deletion |
- | Leu 2278 | deletion |
- | Pro 2279 | deletion |
- | Met 2280 | deletion |
- | Gly 2281 | deletion |
- | Arg 2282 | deletion |
- | Gly 2283 | deletion |
- | Lys 2284 | deletion |
- | Tyr 2285 | deletion |
- | Lys 2286 | deletion |
- | Lys 2287 | deletion |
- | Gly 2288 | deletion |
- | Phe 2289 | deletion |
- | Ser 2290 | deletion |
- | Val 2291 | deletion |
- | Asn 2292 | deletion |
- | Pro 2293 | deletion |
- | Arg 2294 | deletion |
- | Cys 2295 | deletion |
- | Gln 2296 | deletion |
- | Ala 2297 | deletion |
- | Gln 2298 | deletion |
- | Met 2299 | deletion |
- | Glu 2300 | deletion |
- | Glu 2301 | deletion |
- | Arg 2302 | deletion |
- | Ala 2303 | deletion |
- | Leu 2516 | deletion |
- | Ser 2517 | deletion |
- | Arg 2518 | deletion |
- | Lys 2519 | deletion |
- | Arg 2520 | deletion |
- | Lys 2521 | deletion |
- | Leu 2522 | deletion |
- | Gln 2523 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 168712.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1957.7 | |
All* | Total formula weight | 170669.8 |