8E1X

FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fibroblast growth factor receptor 2	polymer	330	37823.2	2	UniProt (P21802) Pfam (PF07714) In PDB	Homo sapiens (human)	FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor
2	A, B	(5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide	non-polymer		446.5	2	Chemie (U9P)
3		water	water		18.0	23	Chemie (HOH)

Sequence modifications

A, B: 459 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 439	-	initiating methionine
Gly 440	-	expression tag
Ser 441	-	expression tag
Ser 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
His 445	-	expression tag
His 446	-	expression tag
His 447	-	expression tag
His 448	-	expression tag
Ser 449	-	expression tag
Ser 450	-	expression tag
Gly 451	-	expression tag
Leu 452	-	expression tag
Val 453	-	expression tag
Pro 454	-	expression tag
Arg 455	-	expression tag
Gly 456	-	expression tag
Ser 457	-	expression tag
His 458	-	expression tag
Ala 491	Cys 491	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75646.4
Non-Polymers*	Number of molecules	2
	Total formula weight	893.0
All*	Total formula weight	76539.4

*Water molecules are not included.