8E1D

NMR-derived ensemble of the TAZ2 domain of p300 bound to the microphthalmia-associated transcription factor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Microphthalmia-associated transcription factor	polymer	34	3720.1	1	UniProt (O75030)	Homo sapiens (human)	Class E basic helix-loop-helix protein 32,bHLHe32
2	B (A)	Histone acetyltransferase p300	polymer	92	10107.9	1	UniProt (Q09472) Pfam (PF02135)	Homo sapiens (human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein 2-hydroxyisobutyryltransferase p300,Protein lactyltransferas p300,Protein propionyltransferase p300
3	C, D, E (A)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)

Sequence modifications

B: 109 - 141 (UniProt: O75030)

PDB	External Database	Details
Gly 108	-	expression tag

A: 1723 - 1812 (UniProt: Q09472)

PDB	External Database	Details
Gly 1721	-	expression tag
Ser 1722	-	expression tag
Ala 1738	Cys 1738	engineered mutation
Ala 1746	Cys 1746	engineered mutation
Ala 1789	Cys 1789	engineered mutation
Ala 1790	Cys 1790	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	13828.0
Non-Polymers*	Number of molecules	3
	Total formula weight	196.2
All*	Total formula weight	14024.3

*Water molecules are not included.