8DZS
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Kappa-type opioid receptor | polymer | 308 | 34928.6 | 1 | UniProt (P41145) Pfam (PF00001) | Homo sapiens (human) | K-OR-1,KOR-1 |
| 2 | B (B) | Guanine nucleotide-binding protein G(z) subunit alpha | polymer | 349 | 39849.6 | 1 | UniProt (P19086) Pfam (PF00503) | Homo sapiens (human) | G(x) alpha chain,Gz-alpha |
| 3 | C (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (E) | ScFv16 protein | polymer | 251 | 26679.7 | 1 | Mus musculus (Mouse) | ||
| 6 | F (A) | methyl (3R)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate | non-polymer | 414.3 | 1 | Chemie (U9I) |
Sequence modifications
A: 54 - 358 (UniProt: P41145)
B: 30 - 355 (UniProt: P19086)
| PDB | External Database | Details |
|---|---|---|
| Leu 51 | - | expression tag |
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| Leu 135 | Ile 135 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Thr 4 | - | expression tag |
| Val 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Lys 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Glu 14 | - | expression tag |
| Arg 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Lys 17 | - | expression tag |
| Met 18 | - | expression tag |
| Ile 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Asn 22 | - | expression tag |
| Leu 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Glu 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Gly 27 | - | expression tag |
| Glu 28 | - | expression tag |
| Lys 29 | - | expression tag |
| Asn 47 | Ser 47 | conflict |
| Ala 204 | Gly 204 | conflict |
| - | Lys 234 | deletion |
| - | Leu 235 | deletion |
| - | Tyr 236 | deletion |
| - | Glu 237 | deletion |
| - | Asp 238 | deletion |
| - | Asn 239 | deletion |
| Ala 246 | Glu 246 | conflict |
| Lys 249 | Arg 249 | conflict |
| Lys 258 | Asn 258 | conflict |
| Asp 262 | Asn 262 | conflict |
| Ser 327 | Ala 327 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 146604.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 414.3 | |
| All* | Total formula weight | 147019.0 |
