8DZS
GR89,696 bound Kappa Opioid Receptor in complex with Gz
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Kappa-type opioid receptor | polymer | 308 | 34928.6 | 1 | UniProt (P41145) Pfam (PF00001) In PDB | Homo sapiens (human) | K-OR-1,KOR-1 |
2 | B | Guanine nucleotide-binding protein G(z) subunit alpha | polymer | 349 | 39849.6 | 1 | UniProt (P19086) Pfam (PF00503) In PDB | Homo sapiens (human) | G(x) alpha chain,Gz-alpha |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
4 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
5 | E | ScFv16 protein | polymer | 251 | 26679.7 | 1 | Mus musculus (Mouse) | ||
6 | A | methyl (3R)-4-[(3,4-dichlorophenyl)acetyl]-3-[(pyrrolidin-1-yl)methyl]piperazine-1-carboxylate | non-polymer | 414.3 | 1 | Chemie (U9I) |
Sequence modifications
A: 54 - 358 (UniProt: P41145)
B: 30 - 355 (UniProt: P19086)
PDB | External Database | Details |
---|---|---|
Leu 51 | - | expression tag |
Gly 52 | - | expression tag |
Ser 53 | - | expression tag |
Leu 135 | Ile 135 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Gly 2 | - | expression tag |
Ser 3 | - | expression tag |
Thr 4 | - | expression tag |
Val 5 | - | expression tag |
Ser 6 | - | expression tag |
Ala 7 | - | expression tag |
Glu 8 | - | expression tag |
Asp 9 | - | expression tag |
Lys 10 | - | expression tag |
Ala 11 | - | expression tag |
Ala 12 | - | expression tag |
Ala 13 | - | expression tag |
Glu 14 | - | expression tag |
Arg 15 | - | expression tag |
Ser 16 | - | expression tag |
Lys 17 | - | expression tag |
Met 18 | - | expression tag |
Ile 19 | - | expression tag |
Asp 20 | - | expression tag |
Lys 21 | - | expression tag |
Asn 22 | - | expression tag |
Leu 23 | - | expression tag |
Arg 24 | - | expression tag |
Glu 25 | - | expression tag |
Asp 26 | - | expression tag |
Gly 27 | - | expression tag |
Glu 28 | - | expression tag |
Lys 29 | - | expression tag |
Asn 47 | Ser 47 | conflict |
Ala 204 | Gly 204 | conflict |
- | Lys 234 | deletion |
- | Leu 235 | deletion |
- | Tyr 236 | deletion |
- | Glu 237 | deletion |
- | Asp 238 | deletion |
- | Asn 239 | deletion |
Ala 246 | Glu 246 | conflict |
Lys 249 | Arg 249 | conflict |
Lys 258 | Asn 258 | conflict |
Asp 262 | Asn 262 | conflict |
Ser 327 | Ala 327 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 146604.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 414.3 | |
All* | Total formula weight | 147019.0 |