8DYL
Crystal structure of human methylmalonyl-CoA mutase bound to aquocobalamin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Methylmalonyl-CoA mutase, mitochondrial | polymer | 762 | 84835.8 | 1 | UniProt (P22033) Pfam (PF01642) Pfam (PF02310) | Homo sapiens (human) | MCM,Methylmalonyl-CoA isomerase |
| 2 | B (B) | COBALAMIN | non-polymer | 1330.4 | 1 | Chemie (B12) | |||
| 3 | C, D, E, F, G... (B) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 4 | I (B) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence modifications
B: 12 - 750 (UniProt: P22033)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | initiating methionine |
| Thr 499 | Ala 499 | conflict |
| Val 671 | Ile 671 | conflict |
| Ala 751 | - | expression tag |
| Glu 752 | - | expression tag |
| Asn 753 | - | expression tag |
| Leu 754 | - | expression tag |
| Tyr 755 | - | expression tag |
| Phe 756 | - | expression tag |
| Gln 757 | - | expression tag |
| Ser 758 | - | expression tag |
| His 759 | - | expression tag |
| His 760 | - | expression tag |
| His 761 | - | expression tag |
| His 762 | - | expression tag |
| His 763 | - | expression tag |
| His 764 | - | expression tag |
| Asp 765 | - | expression tag |
| Tyr 766 | - | expression tag |
| Lys 767 | - | expression tag |
| Asp 768 | - | expression tag |
| Asp 769 | - | expression tag |
| Asp 770 | - | expression tag |
| Asp 771 | - | expression tag |
| Lys 772 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 84835.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1882.9 | |
| All* | Total formula weight | 86718.7 |
