8DYH
IL17A homodimer bound to Compound 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-17A | polymer | 127 | 14537.3 | 2 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | C, E (A, B) | (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine | non-polymer | 345.8 | 2 | Chemie (U5X) | |||
| 3 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 155 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Ser 30 | - | expression tag |
| Ala 31 | - | expression tag |
| Met 32 | - | expression tag |
| Ala 33 | - | expression tag |
| Ser 129 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29074.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 783.7 | |
| All* | Total formula weight | 29858.4 |
