8DY1
Crystal Structure of scFv CAT2200 LH in complex with IL-17A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-17A | polymer | 122 | 14209.9 | 2 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | C, D (C, D) | scFv CAT2200 LH | polymer | 255 | 26616.1 | 2 | Homo sapiens | ||
| 3 | E, F, G, H (C, D) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 73 | Chemie (HOH) |
Sequence modifications
A, B: 12 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | initiating methionine |
| Gln 70 | Lys 93 | engineered mutation |
| Ser 106 | Cys 129 | engineered mutation |
| Gln 132 | Ala 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81652.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 384.3 | |
| All* | Total formula weight | 82036.3 |
