8DVV
Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Ryanodine receptor 2 | polymer | 4966 | 565620.0 | 4 | UniProt (E9Q401) Pfam (PF08709) Pfam (PF01365) Pfam (PF02026) Pfam (PF08454) Pfam (PF13499) Pfam (PF06459) Pfam (PF00520) Pfam (PF02815) Pfam (PF00622) Pfam (PF21119) | Mus musculus (house mouse) | RYR-2,RyR2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor |
| 2 | E, F, G, H (E, F, G, H) | Peptidyl-prolyl cis-trans isomerase FKBP1B | polymer | 107 | 11667.3 | 4 | UniProt (P68106) Pfam (PF00254) | Homo sapiens (human) | PPIase FKBP1B,12.6 kDa FK506-binding protein,FKBP-12.6,FK506-binding protein 1B,FKBP-1B,Immunophilin FKBP12.6,Rotamase,h-FKBP-12 |
| 3 | I, K, M, O (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 4 | J, L, N, P (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
A, B, C, D: 1 - 4966 (UniProt: E9Q401)
| PDB | External Database | Details |
|---|---|---|
| Asp 2030 | Ser 2030 | engineered mutation |
| Asp 2807 | Ser 2807 | engineered mutation |
| Asp 2813 | Ser 2813 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 2309149.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 421.9 | |
| All* | Total formula weight | 2309571.2 |
