8DVL

Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Low-density lipoprotein receptor-related protein 6	polymer	633	71774.6	1	UniProt (O75581) Pfam (PF00058) Pfam (PF14670)	Homo sapiens (human)	LRP-6
2	B (B)	E3.18 Disulfide constrained peptide	polymer	32	3261.8	1		synthetic construct
3	C (C)	alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G11971MR)
4	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
5	E (E)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G09724ZC)
6	F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	H, I, J (A)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
8	K, L, M, N, O... (A)	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
9	R (A)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A: 631 - 1253 (UniProt: O75581)

PDB	External Database	Details
Ser 630	-	expression tag
Ile 1062	Val 1062	variant
Gly 1254	-	expression tag
Asn 1255	-	expression tag
Ser 1256	-	expression tag
His 1257	-	expression tag
His 1258	-	expression tag
His 1259	-	expression tag
His 1260	-	expression tag
His 1261	-	expression tag
His 1262	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75036.4
Branched	Number of molecules	3
	Total formula weight	2214.0
Non-Polymers*	Number of molecules	12
	Total formula weight	997.1
All*	Total formula weight	78247.6

*Water molecules are not included.