8DVL
Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.18
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Low-density lipoprotein receptor-related protein 6 | polymer | 633 | 71774.6 | 1 | UniProt (O75581) Pfam (PF00058) Pfam (PF14670) In PDB | Homo sapiens (human) | LRP-6 |
2 | B | E3.18 Disulfide constrained peptide | polymer | 32 | 3261.8 | 1 | synthetic construct | ||
3 | C | alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G11971MR) | |||
4 | D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
5 | E | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
6 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
7 | A | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
8 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
9 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A: 631 - 1253 (UniProt: O75581)
PDB | External Database | Details |
---|---|---|
Ser 630 | - | expression tag |
Ile 1062 | Val 1062 | variant |
Gly 1254 | - | expression tag |
Asn 1255 | - | expression tag |
Ser 1256 | - | expression tag |
His 1257 | - | expression tag |
His 1258 | - | expression tag |
His 1259 | - | expression tag |
His 1260 | - | expression tag |
His 1261 | - | expression tag |
His 1262 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75036.4 | |
Branched | Number of molecules | 3 |
Total formula weight | 2214.0 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 997.1 | |
All* | Total formula weight | 78247.6 |