8DV2
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Spike glycoprotein | polymer | 1208 | 133753.3 | 1 | UniProt (P0DTC2) Pfam (PF16451) Pfam (PF09408) Pfam (PF19209) Pfam (PF01601) | Severe acute respiratory syndrome coronavirus 2 | S glycoprotein,E2,Peplomer protein |
| 2 | B (D) | Angiotensin-converting enzyme 2,Immunoglobulin gamma-1 heavy chain fusion | polymer | 998 | 113869.3 | 1 | UniProt (Q9BYF1) UniProt (P0DOX5) Pfam (PF01401) Pfam (PF16959) Pfam (PF07654) | Homo sapiens (human) | Angiotensin-converting enzyme homolog,ACEH,Angiotensin-converting enzyme-related carboxypeptidase,ACE-related carboxypeptidase,Metalloprotease MPROT15,Immunoglobulin gamma-1 heavy chain NIE |
| 3 | C, D, E, F, G... (A, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
A: 1 - 1208 (UniProt: P0DTC2)
D: 18 - 740 (UniProt: Q9BYF1)
D: 763 - 994 (UniProt: P0DOX5)
| PDB | External Database | Details |
|---|---|---|
| Gly 682 | Arg 682 | engineered mutation |
| Ser 683 | Arg 683 | engineered mutation |
| Ser 685 | Arg 685 | engineered mutation |
| Pro 986 | Lys 986 | engineered mutation |
| Pro 987 | Val 987 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Phe 31 | Lys 31 | engineered mutation |
| Ile 34 | His 34 | engineered mutation |
| Gln 35 | Glu 35 | engineered mutation |
| Thr 741 | - | linker |
| Ser 742 | - | linker |
| Ser 743 | - | linker |
| Gly 744 | - | linker |
| Gly 745 | - | linker |
| Gly 746 | - | linker |
| Gly 747 | - | linker |
| Glu 748 | - | linker |
| Asn 749 | - | linker |
| Leu 750 | - | linker |
| Tyr 751 | - | linker |
| Phe 752 | - | linker |
| Gln 753 | - | linker |
| Ser 754 | - | linker |
| Ser 755 | - | linker |
| Gly 756 | - | linker |
| Gly 757 | - | linker |
| Gly 758 | - | linker |
| Ser 759 | - | linker |
| Gly 760 | - | linker |
| Gly 761 | - | linker |
| Gly 762 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 995 | - | expression tag |
| Gly 996 | - | expression tag |
| Gly 997 | - | expression tag |
| Gly 998 | - | expression tag |
| Ser 999 | - | expression tag |
| Gly 1000 | - | expression tag |
| Leu 1001 | - | expression tag |
| Asn 1002 | - | expression tag |
| Asp 1003 | - | expression tag |
| Ile 1004 | - | expression tag |
| Phe 1005 | - | expression tag |
| Glu 1006 | - | expression tag |
| Ala 1007 | - | expression tag |
| Gln 1008 | - | expression tag |
| Lys 1009 | - | expression tag |
| Ile 1010 | - | expression tag |
| Glu 1011 | - | expression tag |
| Trp 1012 | - | expression tag |
| His 1013 | - | expression tag |
| Glu 1014 | - | expression tag |
| Gly 1015 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 247622.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1548.5 | |
| All* | Total formula weight | 249171.0 |
