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8DUG

Estrogen Receptor Alpha Ligand Binding Domain in Complex with (6'-hydroxy-1'-(4-(2-((S)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Estrogen receptorpolymer25529033.02UniProt (P03372)
Pfam (PF00104)
Homo sapiens (human)
2C, D
(A, B)
[(1'R)-6'-hydroxy-1'-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanonenon-polymer482.62Chemie (TVF)
3E, F
(A, B)
waterwater18.0141Chemie (HOH)
Sequence modifications
A, B: 301 - 554 (UniProt: P03372)
PDBExternal DatabaseDetails
Met 300-initiating methionine
Ser 381Cys 381engineered mutation
Ser 417Cys 417engineered mutation
Ser 530Cys 530engineered mutation
Ser 536Leu 536engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight58066.0
Non-Polymers*Number of molecules2
Total formula weight965.2
All*Total formula weight59031.3
*Water molecules are not included.

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PDB entries from 2024-11-06

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