8DSR

Structure of Plasmepsin X (PM10, PMX) from Plasmodium falciparum 3D7 in complex with UCB7362

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Plasmepsin X	polymer	465	52764.5	2	UniProt (Q8IAS0) Pfam (PF00026)	Plasmodium falciparum 3D7	PfPMX,Plasmepsin 10
2	C, D (A, B)	(2E,6S)-6-{2-chloro-3-[(2-cyclopropylpyrimidin-5-yl)amino]phenyl}-2-imino-6-methyl-3-[(2S,4S)-2-methyloxan-4-yl]-1,3-diazinan-4-one	non-polymer		469.0	2	Chemie (TWU)

Sequence modifications

A, B: 225 - 573 (UniProt: Q8IAS0)

PDB	External Database	Details
Tyr 125	-	expression tag
Lys 126	-	expression tag
Ile 127	-	expression tag
Gly 128	-	expression tag
Thr 129	-	expression tag
Lys 130	-	expression tag
Ala 131	-	expression tag
Leu 132	-	expression tag
Pro 133	-	expression tag
Cys 134	-	expression tag
Ser 135	-	expression tag
Glu 136	-	expression tag
Cys 137	-	expression tag
His 138	-	expression tag
Asp 139	-	expression tag
Val 140	-	expression tag
Phe 141	-	expression tag
Asp 142	-	expression tag
Cys 143	-	expression tag
Thr 144	-	expression tag
Gly 145	-	expression tag
Cys 146	-	expression tag
Leu 147	-	expression tag
Phe 148	-	expression tag
Glu 149	-	expression tag
Glu 150	-	expression tag
Lys 151	-	expression tag
Glu 152	-	expression tag
Ser 153	-	expression tag
Ser 154	-	expression tag
His 155	-	expression tag
Val 156	-	expression tag
Ile 157	-	expression tag
Pro 158	-	expression tag
Leu 159	-	expression tag
Lys 160	-	expression tag
Leu 161	-	expression tag
Asn 162	-	expression tag
Lys 163	-	expression tag
Lys 164	-	expression tag
Asn 165	-	expression tag
Pro 166	-	expression tag
Asn 167	-	expression tag
Asp 168	-	expression tag
His 169	-	expression tag
Lys 170	-	expression tag
Lys 171	-	expression tag
Leu 172	-	expression tag
Gln 173	-	expression tag
Lys 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
Glu 177	-	expression tag
Ser 178	-	expression tag
Leu 179	-	expression tag
Lys 180	-	expression tag
Leu 181	-	expression tag
Gly 182	-	expression tag
Asp 183	-	expression tag
Val 184	-	expression tag
Lys 185	-	expression tag
Tyr 186	-	expression tag
Tyr 187	-	expression tag
Val 188	-	expression tag
Asn 189	-	expression tag
Arg 190	-	expression tag
Gly 191	-	expression tag
Glu 192	-	expression tag
Gly 193	-	expression tag
Ile 194	-	expression tag
Ser 195	-	expression tag
Gly 196	-	expression tag
Ser 197	-	expression tag
Leu 198	-	expression tag
Gly 199	-	expression tag
Thr 200	-	expression tag
Ser 201	-	expression tag
Ser 202	-	expression tag
Gly 203	-	expression tag
Asn 204	-	expression tag
Thr 205	-	expression tag
Leu 206	-	expression tag
Asp 207	-	expression tag
Asp 208	-	expression tag
Met 209	-	expression tag
Asp 210	-	expression tag
Leu 211	-	expression tag
Ile 212	-	expression tag
Asn 213	-	expression tag
Glu 214	-	expression tag
Glu 215	-	expression tag
Ile 216	-	expression tag
Asn 217	-	expression tag
Lys 218	-	expression tag
Lys 219	-	expression tag
Arg 220	-	expression tag
Thr 221	-	expression tag
Asn 222	-	expression tag
Ala 223	-	expression tag
Gln 224	-	expression tag
Glu 574	-	expression tag
Asn 575	-	expression tag
Leu 576	-	expression tag
Tyr 577	-	expression tag
Phe 578	-	expression tag
Gln 579	-	expression tag
Gly 580	-	expression tag
Ser 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105529.0
Non-Polymers*	Number of molecules	2
	Total formula weight	938.0
All*	Total formula weight	106467.0

*Water molecules are not included.