8DSM
Human NAMPT in complex with inhibitor ZN-4-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nicotinamide phosphoribosyltransferase | polymer | 499 | 56666.1 | 4 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (human) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | E, J, L, O (A, B, C, D) | (3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide | non-polymer | 658.8 | 4 | Chemie (TK0) | |||
| 3 | F, K, M, P (A, B, C, D) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 4 | G, H, N (A, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | I, Q, R (A, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Leu 492 | - | expression tag |
| Glu 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 226664.3 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3397.9 | |
| All* | Total formula weight | 230062.2 |
