8DSM

Human NAMPT in complex with inhibitor ZN-4-3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Nicotinamide phosphoribosyltransferase	polymer	499	56666.1	4	UniProt (P43490) Pfam (PF18127) Pfam (PF04095) In PDB	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	A, B, C, D	(3S)-N-[(1-benzothiophen-5-yl)methyl]-1-[6-(4-{2-[(2E)-3-(pyridin-3-yl)prop-2-enamido]ethyl}phenyl)thieno[2,3-d]pyrimidin-4-yl]piperidine-3-carboxamide	non-polymer		658.8	4	Chemie (TK0)
3	A, B, C, D	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	A, C	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
5	A, D	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
6		water	water		18.0	64	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	226664.3
Non-Polymers*	Number of molecules	14
	Total formula weight	3397.9
All*	Total formula weight	230062.2

*Water molecules are not included.