8DSH

Human NAMPT in complex with quercitrin and AMPcP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	499	56666.1	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C, E (A, B)	PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER	non-polymer		425.2	2	Chemie (A12)
3	D, F (A, B)	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside	non-polymer		448.4	2	Chemie (QCT)
4	G, H (A, B)	water	water		18.0	554	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113332.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1747.2
All*	Total formula weight	115079.4

*Water molecules are not included.