8DSE
Human NAMPT in complex with substrate NAM and activator quercitrin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nicotinamide phosphoribosyltransferase | polymer | 499 | 56666.1 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (human) | NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | C, I (A, B) | NICOTINAMIDE | non-polymer | 122.1 | 2 | Chemie (NCA) PubChem (936) | |||
| 3 | D, F, H (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 4 | E, J (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) PubChem (1061) | |||
| 5 | G, K (A, B) | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside | non-polymer | 448.4 | 2 | Chemie (QCT) PubChem (5320477) PubChem (5320854) PubChem (5353915) PubChem (5702146) PubChem (6325794) PubChem (6710619) PubChem (11972444) PubChem (12314853) PubChem (12314855) PubChem (12314856) PubChem (12314859) PubChem (16667665) PubChem (16758176) PubChem (18604930) PubChem (21550894) PubChem (23304560) PubChem (24211982) PubChem (25141341) PubChem (26339717) PubChem (40469466) PubChem (40486293) PubChem (44259217) PubChem (49847482) PubChem (54174440) PubChem (69916642) PubChem (51402819) PubChem (51402820) PubChem (51403177) PubChem (51403178) PubChem (5280459) PubChem (5320852) PubChem (5359430) PubChem (124425448) PubChem (124540693) PubChem (10072329) PubChem (15939939) PubChem (162903258) PubChem (89864329) PubChem (90882953) PubChem (144163037) PubChem (162903256) PubChem (162903257) PubChem (162903259) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 972 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Leu 492 | - | expression tag |
| Glu 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
| His 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 113332.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1437.3 | |
| All* | Total formula weight | 114769.5 |
