8DSE

Human NAMPT in complex with substrate NAM and activator quercitrin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	499	56666.1	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (human)	NAmPRTase,Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C, I (A, B)	NICOTINAMIDE	non-polymer		122.1	2	Chemie (NCA)
3	D, F, H (A)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
4	E, J (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
5	G, K (A, B)	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside	non-polymer		448.4	2	Chemie (QCT)
6	L, M (A, B)	water	water		18.0	972	Chemie (HOH)

Sequence modifications

A, B: 1 - 491 (UniProt: P43490)

PDB	External Database	Details
Leu 492	-	expression tag
Glu 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	113332.2
Non-Polymers*	Number of molecules	9
	Total formula weight	1437.3
All*	Total formula weight	114769.5

*Water molecules are not included.